This study looks at how well a new vaccine, called the 20-valent pneumococcal conjugate vaccine (20vPnC), works against pneumonia. Pneumonia is a lung infection caused by bacteria called Streptococcus pneumoniae. The study focuses on people aged 65 or older who are hospitalized with pneumonia confirmed by a chest x-ray. If you join, you'll share information about your health and provide a urine sample to check if the vaccine protects against certain bacteria.

The study compares people who got the vaccine and have pneumonia caused by the vaccine-related bacteria with those who got the vaccine but have pneumonia caused by other things. Participants will be involved for 1 to 2 days, and information about their illness will be collected for 30 days.

• Participation Length: Active for 1-2 days, with data collection for 30 days.
• Eligibility: Must be 65 or older, hospitalized with pneumonia.
• Exclusions: Cannot join if pneumonia symptoms start after 48 hours of hospitalization or if vaccinated within 30 days prior.