This study explores if giving large amounts of fluids through an IV (hyperhydration) can help children with a specific E. coli infection. This type of infection can cause severe problems in the kidneys, called Hemolytic Uremic Syndrome (HUS). HUS can lead to kidney failure, needing treatment like dialysis, and other serious health issues. In the past, doctors usually used a method that didn’t involve much fluid (conservative fluid management). However, some recent studies suggest that giving fluids early might protect the kidneys better. This study will compare the two methods to see which one works best to prevent kidney problems.

• The study involves several visits to the clinic for monitoring.
• Participants may receive compensation for their time and travel.
• There might be risks related to fluid overload, which will be closely monitored.

To join, children must be between 9 months and 21 years old and have a specific type of E. coli infection. They should not have severe kidney issues or other serious health conditions. The study aims to improve the care and outcomes for children with these infections.