This study tests if the new drug, **Nimacimab**, helps people with obesity lose weight. Participants will get weekly shots of Nimacimab, Nimacimab with another drug called **Semaglutide**, or a **Placebo** (a shot with no medicine). The goal is to see if Nimacimab is safe and effective in reducing weight compared to the other options. The study is for people aged **18 to 65** with a Body Mass Index (**BMI**) of 30-45, or 27-30 if they have related health issues like high cholesterol or heart disease. People must be stable in weight for three months before starting and cannot have diabetes or certain other health conditions. They also can't have had weight-loss surgery recently. Participants need to agree to use birth control if they are of childbearing age.

• The study involves weekly injections and regular check-ups.
• It's important to be in good health and stable weight before joining.
• Participants must follow the rules about birth control and health checks.