Type 1 Diabetes (T1D) is a disease where the body can't make insulin, a hormone that helps sugar enter cells for energy. The TrialNet Pathway to Prevention study aims to understand how T1D develops and find ways to prevent it. This study screens relatives of people with T1D to see if they have special proteins called antibodies that might mean they could get diabetes too.

In the Screening part, a blood test checks for these antibodies. If any are found, more tests help determine the risk of developing diabetes. The Monitoring part involves regular follow-ups to track any changes.

Eligible participants include those 2.5 to 45 years old with a close family member with T1D, or those with known antibodies. People with existing diabetes, or who have used insulin or certain medications, cannot join.

Participation involves:

• Regular blood tests and follow-ups
• Potential treatment if diagnosed with T1D during the study
• No costs for tests and check-ups