This study is testing a medicine called **Clofazimine Inhalation Suspension**. It's for people with lung problems like bronchiectasis, where the lungs get damaged and struggle to clear mucus. The study compares this medicine to a placebo, which is a fake treatment with no medicine in it. It aims to see if Clofazimine can help improve lung health and life quality.
Participants will first join a **randomized, double-blind, placebo-controlled** part, meaning neither they nor the doctors know who gets the real medicine or the placebo. If eligible, participants may continue to receive the real medicine in an **open-label extension**, where everyone knows they're getting the actual treatment.
- The study is for adults aged 18-85 years.
- Participants must have certain lung conditions and agree to regular visits and tests.
- Exclusion includes conditions like cystic fibrosis, active tuberculosis, or recent heart problems.
Participants will need to follow guidelines, possibly adjust their current treatments, and ensure no recent trial participation or certain medication use. The goal is to find out if Clofazimine can be a safe and effective addition to existing treatments for lung infections.