Image

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

Exploring new treatments for depression with specialized lipid mediators.

Recruiting
18-65 years
All
Phase 2

This study is for people with depression that doesn't get better with regular medicine. It tests if omega-3 fatty acids (a type of healthy fat found in fish) can help improve depression by reducing inflammation (swelling and irritation in the body). Participants will be randomly assigned to take either omega-3 or a placebo (a harmless pill that doesn't do anything) for 12 weeks. The study will include blood tests and questionnaires to check for changes. Omega-3 may increase compounds that reduce inflammation and help with depression symptoms.

  • The study lasts 12 weeks, and you'll need to take pills and get blood tests.
  • Participants must be 18-65 years old with depression not improved by antidepressants.
  • If you have certain medical conditions or take certain medicines, you might not be eligible.
Study details
    Treatment Resistant Depression
    Inflammation
    Overweight

NCT05774665

Massachusetts General Hospital

8 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

  Other languages supported:

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.