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Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

A trial for older adults with specific leukemia mutation treatment.

Recruiting
18 years and older
All
Phase 2

This study is for older adults or those not fit for intense treatment, who have a type of blood cancer called acute myeloid leukemia (AML) with a FLT3 mutation (a change in the DNA of a gene involved in cell growth). It compares usual treatment with azacitidine and venetoclax to adding gilteritinib, another cancer-fighting drug. Azacitidine helps control cancer cell growth, venetoclax blocks a protein that helps cancer cells live, and gilteritinib stops cancer cells from multiplying. The study wants to see if the combination works better than the usual treatment.

Key Points:

  • The study involves taking medicines in cycles, typically every 28 days, for up to 2 years.
  • Participants will have regular check-ups, blood tests, and bone marrow exams to monitor progress.
  • Eligibility includes being 60 years or older, or younger but unfit for strong treatment, and having specific genetic mutations.
Study details
    Acute Myeloid Leukemia

NCT06317649

National Cancer Institute (NCI)

15 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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