D-PLEX 312 is a study to see if a new drug, called D-PLEX, helps prevent infections after belly surgery. D-PLEX slowly releases a medicine called Doxycycline, which fights bacteria, at the surgery site for about 30 days. This study compares two groups: one getting D-PLEX with regular care and the other getting regular care alone. It includes adults 18 and older having planned colon or rectum surgery with a cut larger than 20 cm.
Participants will be split into two groups by chance, and neither they nor their doctors will know which group they are in. The study will last about two months and will require six follow-up visits to check on the surgery wound and overall health. This includes blood tests and doctor check-ups.
- Study lasts about two months with 6 visits.
- Participants must be having planned colon surgery.
- There are some health conditions that will prevent participation.
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