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A Study of Treatment of Inflammation Before Stem Cell Transplant in People With a Primary Immune Regulatory Disorder (PIRD) and/or an Autoinflammatory Condition

Investigating inflammation treatment before stem cell transplant for immune disorders.

Recruiting
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Phase 2

This study is exploring if treatments like emapalumab or a combination of fludarabine and dexamethasone help prepare people with Primary Immune Regulatory Disorder (PIRD) or an autoinflammatory condition for a stem cell transplant. A stem cell transplant is when new, healthy cells are put into your body to help fight diseases.

Key Points:

  • Duration: You'll need to be a part of the study for the entire transplant process.
  • Visits: Regular visits are needed to check your health and how well the treatment is working.
  • Eligibility: You must be receiving your first transplant, have good organ function, and be free from infections.

To join, you should be able to tolerate certain treatments and have no previous transplants. This study is funded by the FDA's Office of Orphan Products Development (OOPD). Always discuss with your doctor to understand the risks and benefits before participating in any study. Make sure you or your guardian can give permission to join the study.

Study details
    Primary Immune Regulatory Disorder
    Autoimmune Lymphoproliferative
    Immune System Diseases

NCT05787574

Memorial Sloan Kettering Cancer Center

2 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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