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Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

Testing Zanidatamab with standard treatment for advanced HER2-positive bile duct cancer.

Recruiting
18 years and older
All
Phase 3

This study is for people with a type of cancer called biliary tract cancer (BTC), which affects the tubes that carry bile from the liver. The study will test a new treatment called Zanidatamab combined with common cancer drugs Cisplatin and Gemcitabine. Some participants may also receive another drug like Durvalumab or Pembrolizumab, which help the immune system fight cancer. To join, your cancer must be HER2-positive, meaning it has a protein that makes the cancer grow. You should not have had more than two rounds of certain cancer treatments before. You need to be at least 18, have good organ function, and if you're able to have kids, use birth control.

  • Study involves multiple visits for treatment and check-ups.
  • Participants may receive Zanidatamab, Cisplatin, Gemcitabine, and possibly Durvalumab or Pembrolizumab.
  • There might be risks, including side effects from the drugs.
Study details
    Biliary Tract Cancer

NCT06282575

Jazz Pharmaceuticals

2 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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