Study Summary: This study is testing a drug called rocatinlimab to see if it helps people with prurigo nodularis. Prurigo nodularis is a skin condition that causes itchy bumps on the skin. The study will compare rocatinlimab to a placebo, which is a fake treatment that looks like the real one but has no medicine in it. This helps researchers see if the drug truly works. **Key Points:** - The study lasts for 24 weeks. You will need to report how itchy you feel and have your skin checked by doctors. - To join, you must be at least 18 years old and have had prurigo nodularis for at least 3 months with at least 20 bumps. - If you have other skin issues or have been treated with some strong medicines recently, you cannot participate. The study aims to find out if rocatinlimab can reduce itchiness and improve the skin condition. You cannot join if your itchiness is due to other reasons like medications or mental health issues. This study is only for those with a specific diagnosis and treatment history.