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A Research Study to See How Much CagriSema (1.0 mg Once Weekly) Lowers Blood Sugar and Body Weight Compared to Tirzepatide (5 mg Once Weekly) in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both

Study comparing CagriSema and Tirzepatide for blood sugar and weight.

Recruiting
18 years and older
All
Phase 3

People with type 2 diabetes are invited to join a study to test how well a new medicine, called CagriSema, works. CagriSema will be compared to another medicine called tirzepatide. Both medicines aim to lower blood sugar and help with weight loss. Participants will get one of the medicines by chance, like flipping a coin. The study will last up to 1 year and 4 months.

To join, you must be 18 or older, have type 2 diabetes for at least 6 months, and take certain diabetes medicines, like Metformin or SGLT2 inhibitors. Your HbA1c (a measure of blood sugar) should be between 7.0% and 10.5%. You need to have a body mass index (BMI) of 30 or higher.

Pregnant women, or those planning to become pregnant, cannot join. If you have kidney problems or other serious health issues, you may be excluded. You can't join if you've used certain other diabetes or weight-loss drugs recently.

  • The study lasts for up to 1 year and 4 months.
  • Participants will randomly receive either CagriSema or tirzepatide.
  • Some medical conditions or recent drug use may prevent participation.
Study details
    Diabetes Mellitus
    Type 2

NCT06534411

Novo Nordisk A/S

15 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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