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Olanzapine 2.5 vs 5 mg in Quadruplet Nausea/Vomiting Prophylaxis Before High-Dose Melphalan

Comparing olanzapine doses for nausea prevention during melphalan treatment.

Recruiting
18 years and older
All
Phase 3

Individuals undergoing chemotherapy with melphalan often experience nausea and vomiting. This study examines if lower doses of a medication called olanzapine can help reduce these side effects. Olanzapine has been effective in previous studies but can cause sleepiness. We will compare 2.5 mg and 5 mg doses of olanzapine, alongside three other standard medications, to find the dose that best reduces nausea and vomiting with minimal sleepiness.

This is a randomized, double-blinded trial. Randomized means participants are randomly chosen to receive either 2.5 mg or 5 mg doses, while double-blinded means neither the participants nor the researchers know who receives which dose. The study targets patients with multiple myeloma receiving high-dose melphalan before autologous stem cell transplantation.

  • Study includes patients receiving high-dose melphalan.
  • Cannot participate if allergic to olanzapine or taking certain medications.
  • No cost to participants; study covers all related expenses.
Study details
    Multiple Myeloma
    Autologous Stem Cell Transplantation

NCT06588413

Augusta University

13 December 2024

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