This study is for adults with **Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)**, a type of blood cancer that has returned or didn’t respond to treatment. The study checks the safety and effects of a new drug, **NMS-03597812**, for patients who have tried all other treatments. Some patients may have a specific genetic mutation called **TP53**. In the future, the drug might be tested with another medicine called **venetoclax**. Here’s what you need to know: - **Participation:** You'll take the drug as a capsule and may need to visit the doctor regularly for check-ups and tests. - **Safety:** The study will watch for side effects, and you’ll need to agree to use birth control if needed. - **Eligibility:** You must be an adult (18+), able to swallow pills, and not have certain other health issues like specific leukemias or recent surgeries. Before joining, you’ll discuss the potential benefits and risks with your doctor and sign a form to show you understand the study. If you are interested, make sure you meet all the study requirements and are willing to follow the study plan. **Note:** Other specific rules might apply to see if you qualify.