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The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

Join our CDK4/6 Inhibitor Study to explore dosing effects!

Recruiting
65 years and older
All
Phase 3

This study tests a new way to give CDK4/6 inhibitors, which are drugs for Metastatic Breast Cancer (MBC), in people aged 65 or older. Metastatic means cancer that has spread. CDK4/6 inhibitors like palbociclib and ribociclib help stop cancer cells from growing. Usually, these drugs are given at full dose, but they can cause side effects. This study compares starting with a lower dose and increasing it if the patient can handle it. This might help patients stay on the drug longer and get more benefits.

Participants will also take endocrine therapy, which are drugs that block hormones fueling cancer. They can choose which one they prefer with their doctor. Participants will be randomly assigned to one of two groups: one with the usual dosing and the other with the new dosing strategy. The main goal is to see which method helps patients stay on treatment longer.

  • The study is for patients aged 65 or older with specific types of breast cancer.
  • Participants must not have used CDK4/6 inhibitors for their cancer before.
  • Participants will be closely monitored for side effects and treatment effectiveness.
Study details
    Metastatic Breast Cancer

NCT06377852

American Society of Clinical Oncology

2 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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