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CAR T-cell Therapy in Patients With Renal Dysfunction

CAR T-cell therapy for patients with kidney issues in a clinical trial.

Recruiting
18 years and older
All
Phase 2

CAR T-cell therapy is a treatment where a patient's own T-cells (a type of white blood cell) are changed in the lab to attack cancer cells. This study looks at how safe and possible it is to use this treatment in people with kidney problems. The study will use a special kind of chemotherapy called *dose-adjusted lymphodepleting chemotherapy* to prepare patients before giving them CAR T-cell therapy. This is important for people who have kidney issues, like those whose kidneys don't work well, to see if the treatment works for them too.

To join, you must have certain health conditions, like being treated for cancers such as multiple myeloma, leukemia, or lymphoma, and have enough healthy bone marrow to get chemotherapy. Your kidney function should be less than or equal to 60mL/min/1.73m2, which measures how well your kidneys work. You shouldn't join if you have serious brain problems, uncontrolled infections, or are taking high doses of steroids.

  • This study is for those with moderate to severe kidney issues receiving CAR T-cell therapy.
  • Participants must have specific types of cancer and meet certain health requirements.
  • Some health conditions or medications may prevent you from joining.
Study details
    Non-hodgkin Lymphoma
    B Cell
    Multiple Myeloma
    Acute Lymphoblastic Leukemia
    Adult

NCT05909059

Northside Hospital, Inc.

29 December 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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