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A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer

Comparing Divarasib with other treatments for advanced lung cancer.

Recruiting
18 years and older
All
Phase 3

This study is looking at how well a new medicine, divarasib, works and how safe it is for people with a specific type of lung cancer. The cancer is called non-small cell lung cancer (NSCLC) that is advanced or has spread to other parts of the body. It focuses on patients who have a gene change called KRAS G12C. Divarasib will be compared to other medicines called sotorasib or adagrasib, which are already used to treat this cancer.

To join the study, you need to have this specific lung cancer and have tried other treatments that didn’t work. You need to be in good enough health to participate, with a life expectancy of at least 12 weeks. Doctors will check your health to make sure you are a good fit.

  • This study may require multiple visits to the hospital over a certain period.
  • There might be some risks, like side effects from the medicine. Your doctor will discuss these with you.
  • Participants might get compensated for their time and travel.

Talk to your doctor to see if this study might be a good option for you!

Study details
    Non-Small Cell Lung Cancer
    KRAS G12C Lung Cancer

NCT06497556

Hoffmann-La Roche

8 March 2025

Step 1 Get in touch with the nearest study center
Entire USA
Results (undefined sites found)
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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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