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A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

Join a study testing KarXT for Alzheimer's-related psychosis.

Recruiting
55-90 years
All
Phase 3

This study is testing KarXT, a possible treatment for psychosis (seeing or hearing things that aren't there) linked to Alzheimer's Disease (AD), a brain disorder that affects memory. The goal is to see if KarXT is safe and works well in adults who have mild to severe AD and moderate to severe psychosis. Participants will be between 55 and 90 years old and must have a brain scan like an MRI or CT within the past 5 years to rule out other brain diseases. They also need to have had psychotic symptoms for at least two months.

Key Points:

  • Participants must be between the ages of 55 to 90 and have had psychotic symptoms for at least 2 months.
  • Participants need a brain scan (MRI or CT) completed within the past 5 years.
  • People with other mental health conditions or certain lab test irregularities are not eligible.

If you think you fit the criteria and are interested in joining, more specific rules apply, and you should talk to the study team or your doctor.

Study details
    Alzheimer Disease

NCT06585787

Karuna Therapeutics

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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