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A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Testing treatments for specific lung cancer mutations.

Recruiting
18 years and older
All
Phase 2

This study examines how well two combinations of medicines work for a specific type of lung cancer, called EGFR-mutated non-small cell lung cancer. The medicines are amivantamab and lazertinib, or amivantamab with chemotherapy. Amivantamab is an antibody, which is a protein that can help fight cancer. Lazertinib is a drug that blocks signals cancer uses to grow. Chemotherapy uses special medicines to kill cancer cells.

For this study, you need to have a confirmed case of advanced or spreading lung cancer that cannot be cured with surgery. You should have a certain type of mutation in your cancer cells. You should not have had major surgery or uncontrolled pain recently.

  • **Study Length & Visits:** Discuss with your doctor for specific details.
  • **Treatment:** You may receive either combination of medicines.
  • **Risks:** Prior surgeries, pain, or other treatments might affect eligibility.
Study details
    Carcinoma
    Non-Small-Cell Lung

NCT06667076

Janssen Research & Development, LLC

9 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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