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A Study to Evaluate the Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia (MK-1167-008)

Testing MK-1167 for Alzheimer's dementia safety and effectiveness.

Recruiting
55-90 years
All
Phase 2

This study is testing a new medicine, MK-1167, for Alzheimer's Disease (AD) dementia. Alzheimer's is a condition that affects memory and thinking. The study wants to find out if MK-1167 helps improve these symptoms when used with another treatment called acetylcholinesterase inhibitor (AChEI) therapy, which is a usual treatment for AD dementia. Researchers will also see if MK-1167 is safe and if people can handle it well.

Who Can Join?

  • People with mild or moderate AD dementia.
  • Participants need a partner to help with the study.
  • Participants must be on AChEI therapy.

Who Cannot Join?

  • People with other brain diseases or major health problems.
  • Anyone with a history of stroke, seizures, or liver disease.
  • Residents in nursing homes needing constant care.

Things to Know:

  • The study will compare MK-1167 to a placebo (a fake treatment).
  • Participation involves checking how well the medicine works and any side effects.
  • Participants must have someone with them who knows them well to help with the study.
Study details
    Alzheimer Disease
    Dementia

NCT06721156

Merck Sharp & Dohme LLC

2 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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