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Post-Operative Dosing of Dexamethasone in Patients with Brain Tumors After a Craniotomy, PODS Trial

Studying dexamethasone doses for brain tumor surgery recovery.

Recruiting
18 years and older
All
Phase 2

This study looks at how changing doses of a medicine called dexamethasone affects patients after brain surgery (craniotomy). Dexamethasone is a type of medication known as a corticosteroid, which helps reduce swelling and inflammation. Swelling can cause symptoms like headaches or dizziness, so it's important to control. However, taking dexamethasone can lead to side effects such as high blood sugar, high blood pressure, and slower wound healing. This trial compares two dose schedules: the normal dosing schedule (NDS) and a reduced dosing schedule (RDS). Patients are randomly put in one of two groups. One group gets dexamethasone for 15 days (NDS), and the other for 4 days (RDS). Both groups have blood samples taken and scans like MRI or CT during hospital visits. The study aims to see if the shorter RDS schedule causes fewer side effects while still managing swelling effectively.

  • Participation involves regular check-ups and scans.
  • Must be 18 or older with specific brain tumor types.
  • Not suitable for people with certain health conditions or pregnant women.
Study details
    Low Grade Glioma
    Malignant Brain Glioma
    Malignant Brain Neoplasm
    Meningioma

NCT06132685

Emory University

18 January 2025

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