Image

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

Trial testing RO7502175 alone or with other drugs for advanced tumors.

Recruiting
18 years and older
All
Phase 1

This study is checking the safety and effects of a new drug called RO7502175 for people with certain advanced cancers. A cancer is a disease where some cells grow uncontrollably and can spread. This study will also see how RO7502175 works alone or with other drugs like atezolizumab or pembrolizumab. These are known as checkpoint inhibitors, which help the immune system fight cancer cells. The study involves two stages: dose escalation, where they find the safest dose, and dose expansion, where more people try the drug to check how well it works.

Key Points:

  • The study requires a life expectancy of at least 12 weeks and no recent cancer treatments before joining.
  • Pregnant or breastfeeding women, and those with certain infections or conditions, cannot participate.
  • Participants must be willing to provide a tumor sample and need to have measurable disease.
Study details
    Locally Advanced or Metastatic Solid Tumors
    NSCLC
    HNSCC
    Melanoma
    TNBC
    Esophageal Cancer
    Gastric Cancer
    Cervical Cancer
    Colorectal Cancer
    Urothelial Carcinoma
    Clear Cell RCC
    HCC

NCT05581004

Genentech, Inc.

2 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

  Other languages supported:

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.