Image

Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

Evaluating CX-4945 safety in medulloblastoma patients, with or without surgery.

Recruiting
3 years and older
All
Phase 1/2

This study is testing a new medicine called CX-4945 (also known as silmitasertib sodium) for kids with a type of brain tumor called medulloblastoma. Medulloblastoma is a cancer that starts in the brain and can come back after treatment. The study will determine the best dose and check the safety of the medicine. There are two parts of the study: Phase I and Phase II.

In Phase I, the medicine’s dose will start low and gradually increase to find the safest amount for children who haven’t finished growing yet. In Phase II, the study will look at how safe it is for older teens and adults. Some patients may need surgery to remove the tumor, and the study will also explore if the medicine helps during surgery.

  • The study lasts up to 2 years, with medicine given twice daily.
  • Participants may need to have surgery as part of the study.
  • There are eligibility criteria, such as age limits and previous treatments.

It’s important for families to consider the potential risks and benefits before joining the study. Participants must have a recurrent medulloblastoma diagnosis and meet specific health requirements.

Study details
    Medulloblastoma
    Childhood
    Medulloblastoma Recurrent
    Medulloblastoma

NCT03904862

Pediatric Brain Tumor Consortium

8 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

  Other languages supported:

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.