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A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

Comparing two treatments for extensive-stage small cell lung cancer.

Recruiting
18 years and older
All
Phase 3

This study is testing two treatments for a type of lung cancer called **Extensive-Stage Small Cell Lung Cancer (ES-SCLC).** It compares a new drug combination called **BMS-986489** with a drug called **Atezolizumab**. Both treatments are mixed with two other drugs, **Carboplatin** and **Etoposide,** which are usually used to treat this cancer. The study is for people who have not had treatment for this kind of cancer before.

  • **Key Point 1:** The study involves several visits and tests, including imaging scans like CT or MRI.
  • **Key Point 2:** Participants must be healthy enough to do daily activities with little or no help.
  • **Key Point 3:** The study may not be suitable for people with certain health conditions or who have had previous treatments for this cancer.

Participants will need to have at least one tumor outside the brain that can be seen using special scans. If you have certain health problems, like cancer spread to the brain, lung or heart diseases, or nerve damage, you might not be able to join. The study will help doctors understand which treatment works best and is safest for people with ES-SCLC.

Study details
    Extensive-Stage Small Cell Lung Cancer

NCT06646276

Bristol-Myers Squibb

8 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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