This study is for adults aged 18 to 75 years with a condition called generalized Myasthenia Gravis (gMG). gMG is a disease that affects how your muscles work, making them weak and tired. The study tests a new medicine called iptacopan against a fake (placebo) pill to see if it helps people with gMG feel better. Participants will be randomly chosen to receive either the real medicine or the placebo for 6 months while they keep taking their regular treatment for gMG. The study is double-blind, meaning neither the doctors nor the participants know who is getting the real treatment.
Eligibility includes having a positive test for AChR antibodies, which are proteins found in the blood of people with gMG. Participants must also have been dealing with gMG symptoms for a while and not be effectively managed with their current treatments.
Key Points:- The study lasts for 6 months of treatment, followed by a 24-month period where all participants can choose to receive iptacopan.
- Participants must be vaccinated against certain infections before starting the study.
- Women who are pregnant or planning to become pregnant cannot participate.