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A Study to Evaluate the Safety, Tolerability, PK, and PD Effects of AZD2389 in Participants With Liver Fibrosis and Compensated Cirrhosis.

Testing AZD2389's safety in liver fibrosis and cirrhosis patients.

Recruiting
18 years and older
All
Phase 2
Study Summary

This study is for people with liver fibrosis and compensated cirrhosis. Liver fibrosis is when scar tissue forms in the liver, and compensated cirrhosis is when the liver is still working well despite damage. The study checks how safe and tolerable the drug AZD2389 is compared to a placebo (a substance with no active drug). It also looks at how the body absorbs and uses AZD2389.

The study lasts about 9 weeks. Participants will have 1 or 2 visits before treatment, 5 clinic visits during 28 days of treatment, and a follow-up visit. Some visits include overnight stays. The study involves around 36 participants divided into two groups, with some receiving AZD2389 and others receiving a placebo.

To join, you must be 18 or older, have liver disease with fibrosis, and not have significant weight changes recently. Some health conditions, like certain heart diseases or infections, may prevent participation.

  • The study lasts 9 weeks with multiple visits, including overnight stays.
  • A total of 36 participants will be included.
  • Participants receive either AZD2389 or a placebo.
Study details
    Liver Fibrosis
    Hepatic Cirrhosis

NCT06750276

AstraZeneca

1 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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