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Donor-Derived Anti-CD33 CAR T Cell Therapy (VCAR33) in Patients With Relapsed or Refractory AML After Allogeneic Hematopoietic Cell Transplant

Exploring VCAR33 therapy for AML patients post-transplant.

Recruiting
18 years and older
All
Phase 1/2

This study tests a new treatment called VCAR33, a type of therapy using **CAR T cells**. These are special immune cells that are trained to find and attack cancer cells. This treatment is for patients with a kind of blood cancer called **acute myeloid leukemia (AML)**, which has not responded well to other treatments or has come back after a **stem cell transplant**. The study will check if VCAR33 is safe and if it works to help patients. It uses cells from the patient's original stem cell donor, which may help them work better.

Key Points:

  • The study involves several visits and close monitoring for side effects.
  • Participants must have had a previous stem cell transplant and meet certain health requirements.
  • There are risks involved, including potential side effects from the CAR T cell therapy.
Study details
    Leukemia
    Myeloid
    Acute

NCT05984199

Vor Biopharma

9 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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