This study is looking at how well two treatments work for a type of colon cancer that cannot be surgically removed or has spread to other parts of the body. The treatments involve medicines called amivantamab and cetuximab, combined with chemotherapy drugs. Chemotherapy uses strong medicines to kill cancer cells. The study is for adults with specific genes, KRAS, NRAS, and BRAF, that are normal (wild-type) in their cancer. Participants will receive different combinations of these treatments to see which helps them stay cancer-free for longer.

• **Study Duration:** Participation may require regular visits to the study site.
• **Compensation:** There may be compensation for participating in the study.
• **Risks:** Common side effects might include allergic reactions to the medicines used.

To join, you must have a certain type of colorectal cancer and be in good enough health to handle the treatments. However, if you have certain lung diseases, allergies to study drugs, or other cancers, you may not qualify. This study is important to find better treatments for colorectal cancer. Always discuss with your doctor before joining.