REACT is a study to test if a special treatment called microbiota therapy (MT) can help reduce harmful germs that don't respond to usual medicines, known as multi-drug resistant organisms (MDRO). This study is for patients in long-term care facilities. MT uses healthy donor bacteria to replace bad bacteria in the intestines.

Participants must be at least 18 years old, have a specific MDRO, and can’t take certain antibiotics or probiotics during the study. They will receive the therapy through an enema or feeding tube, or just be observed, with follow-up checks on Days 7, 14, 21, and 28. The study lasts 6 months, with data collection on safety and any changes in health.

• The study lasts about 6 months, with multiple follow-up visits.
• Participants may receive MT through an enema or feeding tube.
• Eligibility includes being MDRO colonized and not pregnant.

Exclusions include pregnancy, certain illnesses, and recent use of other treatments. Participants must agree to use birth control and avoid certain activities to ensure safety throughout the study.