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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Comparing longer radiation therapy to standard for brain cancer patients.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for patients with certain types of cancer that have spread to the brain. It compares two types of radiation therapy.

*Fractionated Stereotactic Radiosurgery (FSRS)* gives high doses of radiation over three treatments. The other, *Stereotactic Radiosurgery (SRS)*, gives a single large dose. Both use special equipment to target the tumor.

The study will check if FSRS works better for treating brain cancer. The main goal is to see if FSRS delays the cancer coming back in the brain. Other goals include comparing how long patients live, how quickly cancer spreads in the brain, and side effects of treatments.

Participants will have either FSRS or SRS, each session lasting 30-90 minutes. They will also have CT and MRI scans. Follow-ups happen every 3 to 6 months for up to 5 years after the treatment.

  • Participants must be 18 or older and have specific cancer types.
  • They need 1 to 8 brain tumors, with at least one eligible for study.
  • Participants cannot have had previous brain radiation or certain health issues.
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Study details
    Anatomic Stage IV Breast Cancer AJCC v8
    Metastatic Breast Carcinoma
    Metastatic Digestive System Carcinoma
    Metastatic Lung Non-Small Cell Carcinoma
    Metastatic Malignant Neoplasm in the Brain
    Metastatic Malignant Solid Neoplasm
    Metastatic Melanoma
    Metastatic Renal Cell Carcinoma
    Stage IV Lung Cancer AJCC v8
    Stage IV Renal Cell Cancer AJCC v8

NCT06500455

NRG Oncology

15 March 2025

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