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A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer

Testing new bladder cancer treatments for patients not responding to BCG.

Recruiting
18 years and older
All
Phase 2

This study is testing a treatment for a type of bladder cancer called **Non-Muscle Invasive Bladder Cancer (NMIBC)**, specifically for those who didn’t respond well to a common treatment called **Bacillus Calmette-Guérin (BCG)**. The focus is on using a special drug called **nadofaragene firadenovec**, which might be used alone or with other treatments like chemotherapy or immunotherapy.

**Eligibility:** To join, you must be 18 or older and have high-grade NMIBC that didn’t improve after at least two courses of BCG. You can't have cancer that has spread to muscles or other parts of the body. Also, your life expectancy should be more than two years, and you should be available for the entire study duration.

**Key Points:**

  • The study might last several months, including multiple visits for evaluations.
  • Participants will receive the experimental drug and maybe additional therapies.
  • There are risks involved, such as possible side effects from the treatments.
Study details
    Non-muscle Invasive Bladder Cancer With Carcinoma in Situ

NCT06545955

Ferring Pharmaceuticals

16 March 2025

Step 1 Get in touch with the nearest study center
Entire USA
Results (undefined sites found)
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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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