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A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

Study on RP2 and Nivolumab for metastatic uveal melanoma patients.

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Phase 2/3

This study is testing a new treatment for adults with metastatic uveal melanoma, a type of eye cancer that has spread to other parts of the body. The study compares two treatments: RP2 (an experimental virus therapy) with nivolumab, and nivolumab with ipilimumab, both being cancer-fighting drugs.

To join, you must be 18 or older, have this type of cancer, and meet certain health criteria. Some of these criteria include having no prior treatment with immune checkpoint inhibitors (medicines that help your immune system fight cancer), good liver and kidney function, and no recent major surgeries.

Key Points:

  • The study requires regular doctor visits for check-ups and treatments.
  • Participants cannot have received specific cancer treatments or have certain infections.
  • Compensation details are not specified, but you will be contributing to important cancer research.
Study details
    Metastatic Uveal Melanoma

NCT06581406

Replimune Inc.

9 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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