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Study to Evaluate the Effects of NMRA-323511 Among Healthy Elderly and Adults With Agitation Associated With Dementia Due to Alzheimer's Disease

Examining NMRA-323511 effects on dementia-related agitation in Alzheimer's.

Recruiting
55-90 years
All
Phase 1

This is a research study to test a new drug called NMRA-323511 for its safety and effects on elderly people and adults with dementia, specifically from Alzheimer's disease. The study has two parts. In Part A, healthy older adults aged 65 to 80 will participate. In Part B, adults aged 55 to 90 with Alzheimer's-related agitation will join. Randomized means participants are randomly chosen to receive either the drug or a placebo (a "fake" treatment to compare results). The study is double-blind, meaning neither the participants nor the researchers know who gets the actual drug, to ensure fairness. Placebo-controlled means some people will get the placebo to compare against those receiving the active drug.

  • Part A: Includes a screening (up to 28 days), 10-day treatment, and a follow-up visit.
  • Part B: Includes a screening (up to 28 days), 8-week treatment, and a follow-up visit.
  • Participants must meet specific health criteria and age requirements.

The study aims to improve treatments for Alzheimer's agitation. It's important to read the eligibility criteria carefully and consider possible risks before joining.

Study details
    Alzheimer's Disease
    Healthy Elderly

NCT06546995

Neumora Therapeutics, Inc.

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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