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Found 1,913 clinical trials

Walking Function in Diabetic Peripheral Neuropathy

The purpose of this study is to 1) examine the differences in walking function and movement patterns between individuals with diabetic peripheral neuropathy and healthy adults with no known conditions; 2) examine if receiving feedback on walking form will help change walking patterns; and 3) examine the feasibility, safety, and …

45 years and older
All
Phase N/A

Randomized Trial Comparing Immediate Vs. Deferred Surgery for Symptomatic ERM

Vitrectomy to remove an epiretinal membrane (ERM) is one of the most common procedures performed by retinal surgeons. Patients who present with significant macular changes on optical coherence tomography (OCT) but relatively good vision are often advised to defer surgery until vision declines to 20/40 or worse. However, it is …

50 years and older
All
Phase N/A

Oral N-acetylcysteine for Retinitis Pigmentosa

Retinitis pigmentosa (RP) is an inherited retinal degeneration caused by one of several mistakes in the genetic code. Such mistakes are called mutations. The mutations cause degeneration of rod photoreceptors which are responsible for vision in dim illumination resulting in night blindness. After rod photoreceptors are eliminated, gradual degeneration of …

18-65 years
All
Phase 3

Aldena STAR Particles

The objective of this study is to find out the best method of applying STAR particles to the skin. STAR particles are very small particles with microneedles on the surface that can increase and create small punctures in the skin. The small punctures should allow for different topical medications to …

18-39 years
All
Phase N/A

Assessing Durable Antibody Response to HPV Vaccination

This is a single center, longitudinal cohort study in which subjects will receive 9-valent HPV vaccine according to package insert (i.e., one dose of 9-valent HPV vaccine on day (D) 0 followed by a second dose 2 months later and a third dose 6 months later). Immune responses in the …

18-45 years
All
Phase 4

To Assess the Effect of SCD-044 Treatment on Moderate to Severe Plaque Psoriasis

This is a multicenter, randomized, double-blind, placebo-controlled study in subjects with moderate to severe plaque psoriasis.

18 years and older
All
Phase 2

Open-Label Extension Study of Saroglitazar Magnesium in Participants with Primary Biliary Cholangitis

Open-Label Extension Study of Saroglitazar Magnesium in Participants With Primary Biliary Cholangitis

18 years and older
All
Phase 3

AFS Compared to AHC in Treatment of Necrotizing Fasciitis NF

Necrotizing Fasciitis (NF) is a potentially life-threatening soft tissue infection. This study is comparing acellular fish skin graft (AFS) to standard of care allograft (AHC) in the treatment of NF. The purpose of this study is to compare clinical outcomes and time until autograft take in patients that were treated …

18 years and older
All
Phase 4

A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa

This study aims to find the appropriately safe and effective dose and dosing frequency for eltrekibart in adults with moderate-to-severe hidradenitis suppurativa (HS) for further clinical development. The study will last approximately 62 weeks and may include up to 31 visits.

18-75 years
All
Phase 2

Olorofim Aspergillus Infection Study

The purpose of this study is to compare treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with IFD caused by proven IA or probable lower respiratory tract disease Aspergillus species (invasive aspergillosis, IA).

18 years and older
All
Phase 3

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